I used Python scripting to practically open Substance Designer to everything programming wise and any type of data can be brought in SD.
demo - Audio reactive - mp3 data streaming live in SD drives your graph parameters. Sound on!
Interactive swarms of particles
Code any shader directly, feed it live in SD + connect it to your SD nodes
Mandelbulb rendering - running glsl code directly in SubstanceDesigner 2D viewport.
Shader by evilryu
Original shader https://www.shadertoy.com/view/MdXSWn
Live interactive 2D physics in SD
All the flight traffic over Europe live captured and rendered in SD
simulating crack patterns